Particle Engineering & Micronization Technology Library
Particle Engineering
December 2025
Designing Particle Size Reduction Processes to Control Moisture Content and Form of Hydrates.
Micronizing APIs through jet milling is often required to enhance bioavailability and micronizing hydrates can be challenging due to dehydration and phase conversion. Microsize are experts in particle size reduction for bioavailability enhancement and they have developed processes to reduce dehydration and rehydrate materials before phase changes occur.
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Particle Engineering
August 2024
Unleashing Bioavailability: Particle Size, Salt Form, and the Race Against Disproportionation.
For Active Pharmaceutical Ingredients (APIs) that exhibit low solubility and slow dissolution rates, salt formation is a well-established strategy for increasing the solubility, whereas particle size reduction (PSR) is a primary strategy for enhancing the dissolution rate. In this study, the synergistic interplay of salt formation and particle size reduction was studied for maximizing bioavailability of a poorly soluble API.
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Particle Engineering
May 2024
Feeder Selection for Micronization Processes During Early Phase Drug Development: Minimizing Material Loss and Ensuring Precise Feed Rates.
Microsize is able to select from a wide variety of feeder technologies during development and early phase work, when material quantities are limited but precision is also paramount. Having optionality in feeding technologies allows our development scientists to select the most appropriate solution with respect to the following critical deliverables.
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Particle Engineering
August 2023
Using Co-Jet Milling Methodology to Realize Improved Blending and Powder Flow along with Uniform Particle Size Reduction
Microsize utilizes co-jet milling for certain use cases as one of its many micronization capabilities, and its benefits are outlined and demonstrated herein. Co-jet milling is compared to traditional jet milling of Active Pharmaceutical Ingredients (APIs) and excipients.
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Particle Characterization
July 2023
Developing Robust Particle Size Distribution (PSD) Methods via Laser Diffraction for Micronized Powders
Microsize develops robust particle size distribution (PSD) methods to monitor micronization processes and to release Active Pharmaceutical Ingredients (APIs) and excipients for commercial use. Considerations for developing a robust PSD method via laser diffraction (LD) are described herein.
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